1x might be your first choice if you're a mountain biker, gravel rider, or commuting on flat roads. It's also ideal if your priority is maximum reliability and simple maintenance.

2x might suit you more if you're a road cyclist, gravel rider covering various road surfaces, a tourist, or if you ride in hilly regions. It offers smoother gear transitions.

3x is more complex. While it provides the smoothest gear transitions, it raises the question of whether it's worth it, or if you'll be changing gears constantly. 3x might be the best choice if you're already certain that you need it.

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Generally - why not?
It's what effects how your bike feels every day using it. Whenever it's finding right cadence, tailoring bike to your specific needs.